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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Inhibition of mTORC1 signaling protects kidney from irradiation-induced toxicity via accelerating recovery of renal stem-like cells

Fig. 5

Rapamycin treatment attenuated kidney toxicity induced by irradiation. C57BL/6 J mice exposed to 8.0 Gy of total body irradiation (TBI) and treated with vehicle (Veh) or rapamycin (Rap) starting at 6 h post exposure. Mice treated with rapamycin every other day. Kidney tissues harvested at day 7 (d7) post exposure. a Representative pictures by HE staining. Arrows represent damaged corpuscles. b Acute tubular necrosis (ANT) score in kidneys with or without rapamycin treatment under irradiation conditions. c Immunostaining of CD133 in kidneys with or without rapamycin treatment under irradiation conditions. Arrows represent CD133-positive staining. d Integrated optical density (IOD) of CD133 staining presented via imaging analysis. Bar = 50 μm. *p < 0.05 vs Veh; ***p < 0.001 vs Veh. CTL nonirradiated renal tissues, IHC immunohistochemistry

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