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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: A novel mutation of MSX1 in oligodontia inhibits odontogenesis of dental pulp stem cells via the ERK pathway

Fig. 2

Mutation analysis of the family. a Panoramic radiographs and Sanger chromatograms of all the affected members in the family. Schematic analysis shows the position of congenitally missing teeth (denoted by asterisks) in each of the individuals. b The predicted secondary structure of wild-type (WT) and mutant (MT) MSX1 protein. The translation of mutant MSX1 terminated earlier than the wild-type. c Three-dimensional models of wild-type and mutant MSX1. The mutant MSX1 lost the homeodomain structure to bind DNA

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Stem Cell Research & Therapy

ISSN: 1757-6512