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Table 2 Different preconditioning methods to enhance the interaction of SDF-1 with CXCR4 in AKI models

From: Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury

Year Animal AKI model MSC source Preconditioning Outcomes References
2012 Rat I/R BM Incubation with cytokines or chemical compounds Increased SDF-1 level, migration, survival, secretory capacity [10]
2013 Mice Cisplatin BM Incubation with cytokines or chemical compounds Increased CXCR4 expression, migration, survival, secretory capacity [105]
2014 Rat Gentamicin BM Co-injection Increased CXCR4 and CXCR7 expression, migration, proliferative ability, secretory capacity [108]
2013 Mice I/R BM Co-injection Increased SDF-1 level, migration [109]
2013 Rat I/R BM Hypoxia stimulation Increased HIF-1α and CXCR4 expression, migration, retention time, secretory capacity [114]
2013 Rat I/R BM Genetic modification Increased CXCR4 expression, migration, secretory capacity [115]
  1. AKI acute kidney injury, MSC mesenchymal stem cell, I/R ischemia/reperfusion, BM bone marrow, SDF-1 stromal-derived factor-1, CXCR chemokine (C-X-C motif) receptor, HIF hypoxia-inducible factor
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Stem Cell Research & Therapy

ISSN: 1757-6512