Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury

Table 2 Different preconditioning methods to enhance the interaction of SDF-1 with CXCR4 in AKI models

Year	Animal	AKI model	MSC source	Preconditioning	Outcomes	References
2012	Rat	I/R	BM	Incubation with cytokines or chemical compounds	Increased SDF-1 level, migration, survival, secretory capacity	[10]
2013	Mice	Cisplatin	BM	Incubation with cytokines or chemical compounds	Increased CXCR4 expression, migration, survival, secretory capacity	[105]
2014	Rat	Gentamicin	BM	Co-injection	Increased CXCR4 and CXCR7 expression, migration, proliferative ability, secretory capacity	[108]
2013	Mice	I/R	BM	Co-injection	Increased SDF-1 level, migration	[109]
2013	Rat	I/R	BM	Hypoxia stimulation	Increased HIF-1α and CXCR4 expression, migration, retention time, secretory capacity	[114]
2013	Rat	I/R	BM	Genetic modification	Increased CXCR4 expression, migration, secretory capacity	[115]

AKI acute kidney injury, MSC mesenchymal stem cell, I/R ischemia/reperfusion, BM bone marrow, SDF-1 stromal-derived factor-1, CXCR chemokine (C-X-C motif) receptor, HIF hypoxia-inducible factor

ISSN: 1757-6512