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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Circular RNA CDR1as regulates osteoblastic differentiation of periodontal ligament stem cells via the miR-7/GDF5/SMAD and p38 MAPK signaling pathway

Fig. 1

Expression patterns of CDR1as and miR-7 during osteogenic differentiation of periodontal ligament stem cells (PDLSCs). a Relative expression of CDR1as as determined by qRT-PCR analysis during osteoblast differentiation of PDLSCs at days 0, 3, 7, and 14 (left panel). RNA expression at indicated time points was normalized to day 0. GAPDH was used as an internal control. Relative expression of miR-7 at the indicated time points (right panel). U6 was used as an internal control. b Relative mRNA expression of ALP, BMP2, RUNX2, and OCN at the indicated time points. GAPDH was used as an internal control, relative to day 0 groups. *p < 0.05, **p < 0.001. GAPDH glyceraldehyde 3-phosphate dehydrogenase, ALP alkaline phosphatase, BMP2 bone morphogenetic protein 2, RUNX2 Runt-related transcription factor 2, OCN osteocalcin

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