Fig. 6

CDR1as/miR-7/GDF5 affected the phosphorylation of Smad1/5/8 and p38 MAPK in PDLSCs. Western blot analyses (left) and the relative quantification (right) of phosphorylated Smad1/5/8 (pSmad1/5/8), growth differentiation factor 5 (GDF5), and the internal control β-ACTIN in si-GDF5 (a), si-CDR1as (b), and miR-7 mimic- or inhibitor-treated PDLSCs (c) are shown. Western blot analysis (left) and the relative quantification (right) of phosphorylated p38 mitogen-activated protein kinase (p-p38), total p38 mitogen-activated protein kinase (p38), and the internal control β-ACTIN in si-GDF5 (d), si-CDR1as (e), and miR-7 mimic- or inhibitor-treated PDLSCs (f) are shown. *p < 0.05, **p < 0.001. NC normal control, si small interfering RNA