Skip to main content

Table 7 Anorectal function parameters before and after SMDC implantation (all patients)

From: Skeletal muscle-derived cell implantation for the treatment of sphincter-related faecal incontinence

  Mean (SD) Mean (95% CI)
V-2 V4 V4 – V-2
Anal canal length (mm) 15.9 (6.37) 27.1 (9.47) 11.1 (7.4; 14.8)*
Anal sphincter rest pressure (mmHg) 66.2 (35.00) 72.5 (30.20) 7.0 (−4.63; 18.66)
Anal sphincter maximum squeeze pressure (mmHg) 121.4 (56.82) 130.7 (64.27) 8.9 (−4.09; 21.87)
Threshold volumes for first sensation (ml) 30.5 (24.49) 46.6 (22.09) 16.5 (5.1; 27.9)*
Threshold volumes for desire to defecate (ml) 105.0 (61.59) 100.3 (40.69) 1.5 (−20.7; 23.6)
Threshold volumes for urgency to defecate (ml) 111.8 (65.09) 100.3 (40.69) −3.2 (− 25.9; 19.4)
Maximum tolerable volume (ml) 165.1 (72.98) 164.5 (55.64) 2.9 (−19.5; 25.3)
  1. SMDC skeletal muscle-derived cell, SD standard deviation, CI confidence interval, V visit, V-2 3 months pre implantation, V4 12 months post implantation
  2. *Significant change from baseline according to 95% CI