Fig. 2

Umbilical cord–derived mesenchymal stem cell transplantation inhibits the aberrant T helper 1 (Th1) and Th17 responses in 2-octynoic acid coupled to bovine serum albumin (2OA-BSA)–induced autoimmune cholangitis. a Representative flow cytometric profiles showing the frequencies of Th1 cells in the liver, spleen, and blood. b The frequencies of Th1 cells were quantified. c Representative flow cytometric profiles showing the frequencies of Th17 cells in the liver, spleen, and blood. d The frequencies of Th17 cells were quantified. e Intrahepatic mRNA expressions of interferon-gamma (IFN-γ), interleukin-17A (IL-17A), IL-12, IL-23, T-bet, and RAR-related orphan receptor gamma t (RORγt) were determined by real-time polymerase chain reaction. f Levels of IFN-γ, IL-17A, IL-12, and IL-23 in serum were detected by Luminex. Bars represent the mean ± standard error of the mean (SEM); n = 6 per group. *P <0.05, **P <0.01, ***P <0.001. Abbreviations: PB peripheral blood, SP spleen