Table 2 pMSCs modulate expression of genes involved in endothelial cell (EC) survival, apoptosis, injury, and inflammation
Number | Gene symbol | Gene full name | Glucose mean ΔΔ−2 value | Glucose + CMpMSC mean ΔΔ− 2 value | Fold change, glucose vs glucose + CMpMSC (p < 0.05) | Biological activity |
|---|---|---|---|---|---|---|
1 | CAV1 | Caveolin-1 | 6 | 3 | 2-fold ↓ | Inhibits EC proliferation |
2 | COL18A1 | Collagen, type XVIII, alpha 1 | 463 | 4 | 115-fold ↓ | |
3 | PROCR | Protein C receptor, endothelial | 0.61 | 9.11 | 14.93-fold ↑ | Induces EC survival |
4 | F2R | Protease-activated receptor-1 | 1.8 | 104.45 | 58.02-fold ↑ | |
5 | EDN1 | Endothelin-1 | 1 | 6 | 6-fold ↑ | |
6 | TYMP | Thymidine phosphorylase | 5 | 219 | 43.80-fold ↑ | |
7 | ENG | Endoglin | 60.47 | 1.79 | 33.78-fold ↓ | Induces EC injury |
8 | CX3CL1 | Chemokine ligand 1 | 6.85 | 2.55 | 2.68-fold ↓ | |
9 | F3 | Coagulation factor III, tissue factor | 7.17 | 1.39 | 5.15-fold ↓ | |
10 | THBD | Thrombomodulin | 131.78 | 8.52 | 15.46-fold ↓ | |
11 | IL3 | Interleukin 3 | 47.75 | 0.0006 | 79,583.3-fold ↓ | Induces EC inflammation |
12 | ALOX5 | Arachidonate 5-lipoxygenase | 103.45 | 17.62 | 53.05-fold ↓ | |
13 | FLT1 | Vascular endothelial growth factor receptor 1 | 7.14 | 2.75 | 2.59-fold ↓ |