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Table 2 pMSCs modulate expression of genes involved in endothelial cell (EC) survival, apoptosis, injury, and inflammation

From: Human chorionic villous mesenchymal stem/stromal cells protect endothelial cells from injury induced by high level of glucose

Number Gene symbol Gene full name Glucose mean ΔΔ−2 value Glucose + CMpMSC mean ΔΔ− 2 value Fold change, glucose vs glucose + CMpMSC (p < 0.05) Biological activity
1 CAV1 Caveolin-1 6 3 2-fold ↓ Inhibits EC proliferation
2 COL18A1 Collagen, type XVIII, alpha 1 463 4 115-fold ↓
3 PROCR Protein C receptor, endothelial 0.61 9.11 14.93-fold ↑ Induces EC survival
4 F2R Protease-activated receptor-1 1.8 104.45 58.02-fold ↑
5 EDN1 Endothelin-1 1 6 6-fold ↑
6 TYMP Thymidine phosphorylase 5 219 43.80-fold ↑
7 ENG Endoglin 60.47 1.79 33.78-fold ↓ Induces EC injury
8 CX3CL1 Chemokine ligand 1 6.85 2.55 2.68-fold ↓
9 F3 Coagulation factor III, tissue factor 7.17 1.39 5.15-fold ↓
10 THBD Thrombomodulin 131.78 8.52 15.46-fold ↓
11 IL3 Interleukin 3 47.75 0.0006 79,583.3-fold ↓ Induces EC inflammation
12 ALOX5 Arachidonate 5-lipoxygenase 103.45 17.62 53.05-fold ↓
13 FLT1 Vascular endothelial growth factor receptor 1 7.14 2.75 2.59-fold ↓
  1. CMpMSC conditioned medium of unstimulated pMSCs, pMSC placental mesenchymal stem cell, ↓ decrease, ↑ increase