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Table 3 pMSCs modulate expression of genes mediating endothelial cell (EC) angiogenesis

From: Human chorionic villous mesenchymal stem/stromal cells protect endothelial cells from injury induced by high level of glucose

Number

Gene symbol

Gene full name

Glucose ΔΔ−2 value

Glucose + CMpMSC ΔΔ− 2 value

Fold change, glucose vs glucose + CMpMSC (p < 0.05)

Biological activity

1

AGT

Angiotensinogen

3.3

0.004

825-fold ↓

Inhibits EC angiogenesis

2

COL18A1

Collagen, type XVIII, alpha 1

463

4

115-fold ↓

3

F2R

Protease-activated receptor-1

1.8

104.45

58.02-fold ↑

Induces EC angiogenesis

4

ICAM1

Intercellular adhesion molecule 1

11.5

23.85

2.07-fold ↑

5

PGF

Placental growth factor

3.21

22.27

6.93-fold ↑

6

CCL2

Monocyte chemotactic protein-1 (MCP-1)

17.72

35.67

2.01-fold ↑

7

EDN1

Endothelin-1

1

6

6-fold ↑

Induces EC migration

8

PF4

Platelet factor 4

0.79

3.94

4.98-fold ↑

9

ICAM1

Intercellular adhesion molecule 1

11.5

23.85

2.07-fold ↑

  1. CMpMSC conditioned medium of unstimulated pMSCs, pMSC placental mesenchymal stem cell, ↓ decrease, ↑ increase