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Table 3 pMSCs modulate expression of genes mediating endothelial cell (EC) angiogenesis

From: Human chorionic villous mesenchymal stem/stromal cells protect endothelial cells from injury induced by high level of glucose

Number Gene symbol Gene full name Glucose ΔΔ−2 value Glucose + CMpMSC ΔΔ− 2 value Fold change, glucose vs glucose + CMpMSC (p < 0.05) Biological activity
1 AGT Angiotensinogen 3.3 0.004 825-fold ↓ Inhibits EC angiogenesis
2 COL18A1 Collagen, type XVIII, alpha 1 463 4 115-fold ↓
3 F2R Protease-activated receptor-1 1.8 104.45 58.02-fold ↑ Induces EC angiogenesis
4 ICAM1 Intercellular adhesion molecule 1 11.5 23.85 2.07-fold ↑
5 PGF Placental growth factor 3.21 22.27 6.93-fold ↑
6 CCL2 Monocyte chemotactic protein-1 (MCP-1) 17.72 35.67 2.01-fold ↑
7 EDN1 Endothelin-1 1 6 6-fold ↑ Induces EC migration
8 PF4 Platelet factor 4 0.79 3.94 4.98-fold ↑
9 ICAM1 Intercellular adhesion molecule 1 11.5 23.85 2.07-fold ↑
  1. CMpMSC conditioned medium of unstimulated pMSCs, pMSC placental mesenchymal stem cell, ↓ decrease, ↑ increase