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Table 5 pMSCs modulate expression of genes involved in endothelial cell (EC) survival, apoptosis, injury, fibrosis formation, and inflammation

From: Human chorionic villous mesenchymal stem/stromal cells protect endothelial cells from injury induced by high level of glucose

Number Gene symbol Gene full name Glucose ΔΔ−2 value Glucose + ICpMSC ΔΔ− 2 value Fold change, glucose vs. glucose + ICpMSC (p < 0.05) Biological activity
1 PLAT Plasminogen activator, tissue 4.52 247.12 54.67-fold ↑ Induces EC proliferation
2 PDGFRA Platelet-derived growth factor receptor, alpha polypeptide 38 76 2-fold ↑
3 CAV1 Caveolin-1 6 2 3-fold ↓ Inhibits EC proliferation
4 COL18A1 Collagen, type XVIII, alpha 1 463 19 24-fold ↓
5 PROCR Protein C receptor, endothelial 0.61 7.69 12.6-fold ↑ Induces EC survival
6 F2R Protease-activated receptor-1 1.8 10.91 6.06-fold ↑
7 TGFB1 Transforming growth factor beta 1 0.96 37.26 138-fold ↑
8 BCL2L1 BCL2-like 1 1.4 140.43 100.3-fold ↑
9 MMP1 Matrix metallopeptidase 1 1.06 24 22.64-fold ↑
10 KDR Vascular endothelial growth factor receptor 3 (VEGFR3) 0.62 50.83 81.92-fold ↑
11 SPHK1 Sphingosine kinase 1 1330.29 1,156,189.43 869.12-fold ↑
12 TNFSF10 TNF-related apoptosis-inducing ligand (TRAIL) 1.65 1788.25 1083-fold ↑
13 FASLG Fas ligand 18,254.05 9.84 1855.08-fold ↓ Induces EC apoptosis
14 ENG Endoglin 60.47 1.89 31.99-fold ↓ Induces EC injury
15 AGTR1 Angiotensin II receptor, type 1 2366.34 227.48 10.4-fold ↓
16 THBD Thrombomodulin 131.78 10.19 12.93-fold ↓
17 IL3 Interleukin 3 47.75 0.59 80.93-fold ↓ Induces EC inflammation
18 ALOX5 Arachidonate 5-lipoxygenase 103.45 0.82 126.15-fold ↓
19 FLT1 Vascular endothelial growth factor receptor 1 7.14 1.96 3.64-fold ↓
  1. ICpMSC intercellular direct contact experiment, pMSC placental mesenchymal stem cell, TNF tumour necrosis factor, ↓ decrease, ↑ increase