Table 5 pMSCs modulate expression of genes involved in endothelial cell (EC) survival, apoptosis, injury, fibrosis formation, and inflammation
Number | Gene symbol | Gene full name | Glucose ΔΔ−2 value | Glucose + ICpMSC ΔΔ− 2 value | Fold change, glucose vs. glucose + ICpMSC (p < 0.05) | Biological activity |
|---|---|---|---|---|---|---|
1 | PLAT | Plasminogen activator, tissue | 4.52 | 247.12 | 54.67-fold ↑ | Induces EC proliferation |
2 | PDGFRA | Platelet-derived growth factor receptor, alpha polypeptide | 38 | 76 | 2-fold ↑ | |
3 | CAV1 | Caveolin-1 | 6 | 2 | 3-fold ↓ | Inhibits EC proliferation |
4 | COL18A1 | Collagen, type XVIII, alpha 1 | 463 | 19 | 24-fold ↓ | |
5 | PROCR | Protein C receptor, endothelial | 0.61 | 7.69 | 12.6-fold ↑ | Induces EC survival |
6 | F2R | Protease-activated receptor-1 | 1.8 | 10.91 | 6.06-fold ↑ | |
7 | TGFB1 | Transforming growth factor beta 1 | 0.96 | 37.26 | 138-fold ↑ | |
8 | BCL2L1 | BCL2-like 1 | 1.4 | 140.43 | 100.3-fold ↑ | |
9 | MMP1 | Matrix metallopeptidase 1 | 1.06 | 24 | 22.64-fold ↑ | |
10 | KDR | Vascular endothelial growth factor receptor 3 (VEGFR3) | 0.62 | 50.83 | 81.92-fold ↑ | |
11 | SPHK1 | Sphingosine kinase 1 | 1330.29 | 1,156,189.43 | 869.12-fold ↑ | |
12 | TNFSF10 | TNF-related apoptosis-inducing ligand (TRAIL) | 1.65 | 1788.25 | 1083-fold ↑ | |
13 | FASLG | Fas ligand | 18,254.05 | 9.84 | 1855.08-fold ↓ | Induces EC apoptosis |
14 | ENG | Endoglin | 60.47 | 1.89 | 31.99-fold ↓ | Induces EC injury |
15 | AGTR1 | Angiotensin II receptor, type 1 | 2366.34 | 227.48 | 10.4-fold ↓ | |
16 | THBD | Thrombomodulin | 131.78 | 10.19 | 12.93-fold ↓ | |
17 | IL3 | Interleukin 3 | 47.75 | 0.59 | 80.93-fold ↓ | Induces EC inflammation |
18 | ALOX5 | Arachidonate 5-lipoxygenase | 103.45 | 0.82 | 126.15-fold ↓ | |
19 | FLT1 | Vascular endothelial growth factor receptor 1 | 7.14 | 1.96 | 3.64-fold ↓ |