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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Induction of CD4+CD25+FOXP3+ regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and TSDR demethylation

Fig. 7

Infusion of BM-MSCs delays skin graft rejection via modification of cytokine secretion profile of T cells. BALB/c mice grafted with full-thickness allogeneic back skin from C57BL/6 mice and treated with MSCs or cyclosporin as described in Methods. Mice sacrificed on day 5, 10, or 15 after transplantation, and serum levels of TNF-α, INF-γ, IL-4, IL-5, IL-17, IL-6, IL-21, IL-2, and IL-10 measured. Data presented as mean ± SEM; n = 5 in each group. Significant results: *p < 0.05; **p < 0.01; ***p < 0.001. CsA cyclosporin A, IL interleukin, INF interferon, MSC mesenchymal stem cell, TNF tumor necrosis factor

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Stem Cell Research & Therapy

ISSN: 1757-6512