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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Induction of bone marrow-derived cells myogenic identity by their interactions with the satellite cell niche

Fig. 7

Analysis of regenerating muscles electroporated with either control plasmid (H2B-RFP) or plasmid coding Sdf-1 to which CXCR4+BMCs(β-gal+) were transplanted. Muscles were analyzed 12 days after injury, i.e., 7 days after cell injection and 8 days following electroporation. a Localization of transplanted cells; control, freshly isolated and sorted CXCR4+BMCs(β-gal+) (ctrl) or pretreated (p-t) by coculture for 5 days in the presence of Sdf-1 with myofibers CXCR4+BMCs(β-gal+) in regenerating muscle. b ELISA assessed Sdf-1 levels in skeletal muscles electroporated either with control or plasmid encoding Sdf-1 (n = 6). c Percentage of myofibers with the participation of CXCR4+BMCs(β-gal+) transplanted into muscles electroporated either with control or plasmid encoding Sdf-1 (n = 6). ***p < 0.001. β-gal β-galactosidase, BMC bone marrow-derived cell

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