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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Gene expression profiling of chondrogenic differentiation by dexamethasone-conjugated polyethyleneimine with SOX trio genes in stem cells

Fig. 4

Microarray analysis of hMSCs transfected with DI-NPs and cultured for 7 days in a 3D system. a Schematic illustration of the microarray analysis. b Heatmap showing the expression of genes related to differentiation and proliferation in each group of transfected human mesenchymal stem cells (hMSCs) relative to nontreated hMSCs. c Log2 fold-changes in the gene expression of COLII, SOX9, PCNA, and Ki67 in each group of transfected hMSCs relative to nontreated hMSCs: hMSCs transfected with DEX/PEI only (panel a), SOX5-complexed DEX/PEI (panel b), SOX6-complexed DEX/PEI (panel c), SOX9-complexed DEX/PEI (panel d), and SOX5/6/9 (trio)-complexed DEX/PEI (DI-NPs) (panel e). n = 5. COL collagen

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Stem Cell Research & Therapy

ISSN: 1757-6512