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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

Fig. 5

Responses of articular chondrocytes to stimulation by MSC- miR-92a-3p-Exos. MiR-92a-3p (a, b) expression level changes in exosomes after treatment of chondrocytes with MSC-miR-Control-Exos, MSC-miR-92a-3p-Exos, MSC-anti-miR-Control-Exos or MSC-anti-miR-92a-3p-Exos were determined by qRT-PCR. U6 was used as an endogenous control. Gene expression levels of aggrecan (c), COL2A1 (d), COL9A1 (e), COMP (f), SOX9 (g), COL10A1 (h), RUNX2(i), MMP13(j), and WNT5A(k) were estimated by qRT-PCR. Quantitative data are presented as means ± standard deviations of three independent experiments. GAPDH was used as an internal control. *P < 0.05, **P < 0.01, ***P < 0.001. l Protein expression levels of aggrecan, col2a1, SOX9, RUNX2, MMP13, and Wnt5a were visualized by western blotting. GAPDH was used as an endogenous control

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Stem Cell Research & Therapy

ISSN: 1757-6512