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Table 1 Summary of the clinical effect of dental-derived stem cells (DSCs)

From: Mechanisms underlying dental-derived stem cell-mediated neurorestoration in neurodegenerative disorders

Clinical trial number

Study type

Phase

n

Disease type

Length of trial (months)

DSC type

Status

Observed changes

Reference

NCT03386877

Periodontal regeneration using DPSCs

_

29

Periodontal diseases

15 (January 2016 to April 2017)

DPSCs

Completed

Not known

[136]

NCT02523651

Periodontal regeneration of chronic periodontal disease patients receiving stem cell injection therapy

I and II

40

Periodontal diseases

24 (December 2014 to December 2016)

1×106 DPSCs immediately after periodontal scaling and root planing

Unknown

Change from baseline alveolar bone volume

–

NCT01814436

Revitalization of immature permanent teeth with necrotic pulp using SHEDs

I

80

Permanent incisor avulsed by trauma

58 (February 2013 to October 2017)

SHEDs

Active

Pulp and apical regenerated

–

NCT02464202

Use of CBCT-based tooth replica in tooth autotransplantation to improve the outcome of tooth replacement in children

_

100

Increase success rate of tooth transplantation

56 (February 2013 to October 2017)

PDLSCs

Active

Not known

–

NCT02731586

Effect on allogenic MSCs on osseointegration of dental implants

Early phase I

10

Edentulous alveolar ridge

27 (January 2016 to March 2018)

Dental pulp-derived allogenic MSCs

Active

Not known

–

NCT02449005

Autologous ABMSCs for the reconstruction of infrabony periodontal defects (PerioRegen)

I and II

30

Chronic periodontitis

45 (January 2014 to September 2017)

ABMSCs

Active

Gain in clinical attachment level

–

NCT03137979

GMSC treatment of chronic periodontitis

I and II

30

Periodontitis

36 (January 2017 to December 2019)

GMSCs, collagen scaffolds, and open flap debridement

Active

An increase in the height of alveolar bone in mm

–

NCT01357785

Periodontal tissue regeneration using autologous PDLSCs

I

35

Periodontal pocket

32 (April 2011 to December 2014)

Autologous PDLSCs

Unknown

Increase in alveolar bone height and gain in clinical attachment level

[137]

NCT01082822

PDLSC implantation in the treatment of periodontitis

I and II

80

Chronic periodontitis

24 (January 2010 to January 201)2

PDLSC implantation (fabricated cell sheet pellets and cell sheet fragment)

Unknown

Not known

–

  1. ABMSC alveolar bone-derived mesenchymal stem cell, CBCT cone beam computed tomography, DPSC dental pulp stem cell, GMSC gingiva mesenchymal stem cell, MSC mesenchymal stem cell, PDLSC periodontal ligament stem cell, SHED stem cell from human exfoliated deciduous teeth; n = no of participants