Fig. 3
From: Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells
Gene expression of MSCs under long-term and short-term hypoxia. a In long-term cultures, TF, VEGF, and Ang-1 genes are upregulated in pMSCs under hypoxia. In hMSCs, VEGF (p = 0.08) and BAX (p < 0.05) were upregulated under hypoxia while HMGB1 (p = 0.08) was downregulated. (b) In short-term hypoxia culture, VEGF (p = 0.07) was upregulated while NANOG (p < 0.01) was downregulated in pMSCs. In hMSCs, VEGF (p < 0.05) was upregulated under hypoxia while the pro-apoptotic genes, BCL-2 (p < 0.01) and CASP-3 (p < 0.05), were downregulated. *p < 0.05; **p < 0.01; ***p < 0.001