Fig. 7

Gene expression under 2% and 5% short-term hypoxia. (a) Under 2% short-term hypoxia, there was a significant upregulation in the angiogenic gene, VEGF, with a concomitant downregulation in the expression of HMBG1 in both human and porcine MSCs. Additionally, under hypoxia, the stem cell gene, NANOG, was downregulated in porcine, but not human MSCs, while TF and HIF antagonist were downregulated in human, but not porcine MSCs. (b) Similar to 2% hypoxia, under 5% hypoxia, the VEGF gene was significantly upregulated under hypoxia in both human and porcine MSCs, while HMGB1 and HIF antagonist were downregulated in hMSCs. As opposed to 2% hypoxia, TF was significantly upregulated in pMSCs under 5% hypoxia; ^*p < 0.05; ^**p < 0.01; ^***p < 0.001; ^****p < 0.0001