Fig. 1
From: The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure
The possible mechanisms of bone marrow-derived mesenchymal stem cells (BMSCs). The migration of BMSCs is associated with CXCL8 and HGF. HGF, VEGF, IGF-1, TGF, bFGF, and GMCSF, secreted by BMSCs, contribute to inhibiting apoptosis. VEGF and HGF play an important role in angiogenesis. The mechanism of antioxidation is still unknown. ADM adrenomedullin, bFGF basic fibroblast growth factor, CXCL8 C-X-C chemokine ligand-8, GMCSF granulocyte macrophage colony-stimulating factor, HGF hepatocyte growth factor, HLAG5 human leukocyte antigen G5, IDO indoleamine 2,3-dioxygenase, IGF1 insulin-like growth factor-1, IL interleukin, iNOS inducible nitric oxide synthase, MCP1 monocyte chemoattractant protein 1, PGE2 prostaglandin E2, TGF transforming growth factor, TNF tumor necrosis factor, Treg regulatory T, VEGF vascular endothelial growth factor