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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: TSG-6 secreted by human adipose tissue-derived mesenchymal stem cells ameliorates severe acute pancreatitis via ER stress downregulation in mice

Fig. 1

Effects of intraperitoneally injected hAT-MSCs on caerulein- and LPS-co-induced severe acute pancreatitis (SAP). Mice were treated with caerulein (50 μg/kg, six times) and LPS (10 mg/kg) to induce SAP. Mice were sacrificed 12, 24, and 48 h after hAT-MSCs infusion. a Representative pathological changes in H&E-stained pancreatic tissue sections at ×200 magnification. b, c, d Histological analysis of the severity of acute pancreatitis. e The ratio of pancreas weight to body weight was measured. f, g The activities of digestive enzymes such as serum amylase and lipase were measured. Each value represents the mean ± SD. *P < 0.05, **P < 0.01, aP < 0.01 versus SAP + PBS group at the same time point; bP < 0.01 versus MSC sham group at the same time point (n = 5–8 mice per group), MSC mesenchymal stem cells, PBS phosphate-buffered saline, SAP severe acute pancreatitis

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