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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Mesenchymal stromal cells from myelodysplastic and acute myeloid leukemia patients display in vitro reduced proliferative potential and similar capacity to support leukemia cell survival

Fig. 1

MSCs derived from MDS and AML patients show normal morphology but reduced proliferative capacity. a MSCs isolated at P1 normalized to number of BM-derived mononuclear cells seeded in three analyzed groups. Results expressed as mean ± SEM calculated from data obtained from independent samples of HDs (N = 9), MDS patients (N = 19), AML patients (N = 16) (*P < 0.05; **P < 0.01). b Representative field of exponential growing culture of HD-MSCs, MDS-MSCs, and AML-MSCs. Magnification 10×; scale bar, 100 μm. c Comparison of cell counts in BM-derived HD-MSCs, MDS-MSCs, and AML-MSCs at each passage. Results expressed as mean ± SEM calculated from data obtained from at least seven independent samples (***P < 0.001 at P5). MSC mesenchymal stromal cell, MNC mononuclear cell, HD-MSC mesenchymal stromal cell from healthy donor, MDS-MSC mesenchymal stromal cell from myelodysplastic syndrome patient, AML-MSC mesenchymal stromal cell from acute myeloid leukemia patient, P cell culture passage

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