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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Mesenchymal stromal cells from myelodysplastic and acute myeloid leukemia patients display in vitro reduced proliferative potential and similar capacity to support leukemia cell survival

Fig. 3

AML-MSCs and MDS-MSCs do not show tumor-specific chromosomal abnormalities. Representative samples analyzed by fluorescent in-situ hybridization (FISH). CBFβ/MYH11 Translocation, Dual Fusion Probe, and RB1 Deletion Probe used to investigate chromosome 16 (a, b) and chromosome 13 abnormalities (c, d), respectively. a BM-derived mononuclear cell with abnormal FISH pattern isolated from an AML patient. b MSC with normal FISH pattern isolated from same AML patient. c Schematic illustration of FISH probes and FISH signal pattern (d). BM-derived mononuclear cell with abnormal FISH pattern isolated from an MDS patient. e MSC with normal FISH pattern isolated from same MDS patient. f Schematic illustration of FISH probes and FISH signal pattern. Magnification (100×). Scale bar 10 μm. MDS-MSC mesenchymal stromal cell from myelodysplastic syndrome patient, AML-MSC mesenchymal stromal cell from acute myeloid leukemia patient

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