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Table 2 DBMSCs modulate the expression of genes involved in endothelial cell (EC) survival, apoptosis, injury, fibrosis formation, and inflammation. THUVEC (HUVEC were cultured with 100 μM H2O2 for 48 h). TDBMSC (HUVEC were cultured with DBMSC and 100 μM H2O2 for 48 h)

From: Human decidua basalis mesenchymal stem/stromal cells protect endothelial cell functions from oxidative stress induced by hydrogen peroxide and monocytes

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Gene symbol

Gene full name

THUVEC mean ΔΔ−2 values

TDBMSC Mean ΔΔ−2 values

Fold change (TDBMSC Vs. THUVEC)

P < 0.05

Biological activities

1

BCL2

B-cell Lymphoma 2

2

23

11.5-fold ↑

Induce EC survival

2

EDN1

Endothelin-1

12

82

> 6.64-fold ↑

3

EDNRA

Endothelin-1 (ET-1) Receptor A

3

9

3-fold ↑

4

HMOX1

Heme Oxygenase-1

7

158

20-fold ↑

5

KDR

Vascular Endothelial Growth Factor Receptor 3 (VEGFR3)

2

52

22.57-fold ↑

6

MMP2

Matrix Metallopeptidase 2

9

36

4-fold ↑

7

SPHK1

Sphingosine Kinase 1

44

840,958

19112.68-fold ↑

8

MMP9

Matrix Metallopeptidase 9

1

6

6-fold ↑

9

PECAM1

Platelet endothelial cell adhesion molecule

1090

7242

6.64-fold ↑

10

TNFSF10

TNF-related apoptosis-inducing ligand (TRAIL)

7

30

> 4.20-fold ↑

11

TYMP

Thymidine Phosphorylase

5

27

> 5-fold ↑

12

FAS

Fas cell surface death receptor

3

0.76

> 3-fold ↓

Induce EC apoptosis

13

PF4

Platelet Factor 4

21

0.69

> 30-fold ↓

14

HIF1α

Hypoxia-Inducible Factor-1α

159

11

> 14-fold ↓

Induce EC injury

15

SERPINE1 (PAI-1)

Type 1 plasminogen activator inhibitor

997

248

4-fold ↓

16

TIMP1

TIMP Metallopeptidase Inhibitor 1

3

1

3-fold ↓

17

ACE

Angiotensin I Converting Enzyme

15,765

5

3153-fold ↓

18

F2R

Coagulation Factor II Thrombin Receptor

20

1

20-fold ↓

Induce EC inflammation

19

ADAM17

A disintegrin and Metalloprotease 17

256

4

64-fold ↓

20

FLT1

Vascular Endothelial Growth Factor Receptor 1

23

12

1.91-fold ↓

21

TNF-α

Tumor Necrosis Factor-α

591

2

> 295-fold ↓

22

PTK2

PTK2 protein tyrosine kinase 2 (PTK2) or focal adhesion kinase (FAK),

8

2

4-fold ↓

Inhibits inflammation and fibrosis

23

PLG

Plasminogen

8

90

> 11-fold ↑

Inhibits inflammation and, promotes fibrin clearance

24

F3

Coagulation Factor III, Tissue Factor

30

0.06

500-fold ↓

Induces EC injury by induction of fibrin and thrombus formation

25

THBD

Thrombomodulin

1013

1

1013-fold ↓

26

THBS1

Thrombospondin 1 (TSP-1)

1097

3

> 365-fold ↓

Induces EC inflammation and injury

27

TFPI

Tissue Factor Pathway Inhibitor

11

23

~ 2-fold ↑

Inhibits EC injury by reducing thrombus formation