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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: MicroRNA-9 modified bone marrow-derived mesenchymal stem cells (BMSCs) repair severe acute pancreatitis (SAP) via inducing angiogenesis in rats

Fig. 2

pri-miR-9-BMSCs promote angiogenesis. a Angiogenesis-related genes (CXCR4, Ang-1, TIE-2, and CD31) were significantly upregulated after pri-miR-9-BMSC transplantation, compared with SAP, SAP+PBS, BMSCs, or TuD-BMSCs groups. Anti-angiogenic genes (VE-cadherin, β-catenin) were significantly decreased compared with SAP, SAP+PBS, BMSCs, EV-BMSCs, or TuD-BMSCs groups. The PI3K/AKT signaling pathway (PI3K, p-AKT, AKT) was activated by pri-miR-9-BMSCs. Data are shown as the mean ± SD for at least 3 separate experiments. *p < 0.05, **p < 0.01 and ***p < 0.001, compared with NC, ++p < 0.01 and +++p < 0.001, compared with SAP, $p < 0.05 and $$p < 0.01, compared with SAP+PBS, #p < 0.01,##p < 0.001, compared with BMSCs, &p < 0.05,&&p < 0.01, compared with EV-BMSCs, @p < 0.05,@@p < 0.01, compared with TuD-BMSCs. b The results of IHC showed that the CD31 and CD34 were significantly upregulated by pri-miR-9-BMSCs. Data are shown as the mean ± SD. ***p < 0.001, compared with pancreas by using two-tailed t test

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