Fig. 3

MSCT inhibited human and mouse IL-12 both in vivo and in vitro. a Serum IL-12 levels in SS patients before and 7 days after MSCT (n = 10). b Serum IL-12 levels of mice at day 28 post MSC/FLS/PBS treatment (n = 5 for each group). c IL-12 mRNA expression in sorted splenic CD11c+ cells 28 days after MSC/FLS/PBS treatment (n = 5 for each group). d IL-12 mRNA expression in human monocyte-derived DCs cultured alone or co-cultured with MSCs (n = 3). e IL-12 mRNA expression in sorted splenic CD11c+ cells from C57BL/6 mice cultured alone or co-cultured with MSCs (n = 4). Data for a, d, and e are analyzed by paired Student t test, and data for b and c are analyzed by one-way ANOVA. Error bars denote ± SD. **p < 0.01, ***p < 0.001