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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Identifying deer antler uhrf1 proliferation and s100a10 mineralization genes using comparative RNA-seq

Fig. 2

RM cells exhibit increased proliferation and osteogenic differentiation compared to hMSCs. a RM cells exhibited increased proliferation relative to hMSCs. b Cell cycle analysis showed an increased proportion of RM cells undergoing cell division relative to hMSCs. c RM cells were capable of chondrogenic but not adipogenic differentiation. d RM cells (isolate 2) cultured with 100 ng/mL BMP-2 for 6 days exhibited increased osteogenic gene expression relative to their respective control. e RM cells cultured with 100 ng/mL BMP-2 and 100 nM dexamethasone for 24 days exhibited increased Alizarin Red S staining relative to hMSCs. Scale bars as indicated. Data were from n = 3 isolates (three independent experiments with nine replicates per isolate for proliferation and chondrogenic, adipogenic, and mineralization studies and one independent experiment with three replicates per isolate for cell cycle studies) or n = 1 isolate (two independent experiments with six replicates for osteogenic gene expression studies). Gray circles indicate observed data points. Error bars indicate SEM. Statistical significance as indicated

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