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Table 3 Cluster of differentiation proteins (CD) identified in equine AT-MSCs and/or equine BM-MSCs and their characteristics in relation to AT-MSCs and BM-MSCs described in the literature

From: Mapping of equine mesenchymal stromal cell surface proteomes for identification of specific markers using proteomics and gene expression analysis: an in vitro cross-sectional study

Protein

Gene name

Characteristics

References

Identified cluster of differentiation proteins previously reported as present on the surface of equine MSCs

CD29

ITGB1

Consistently observed equine MSCs surface protein. Positive human MSCs surface marker according to ISCT

[5, 7, 19, 21]

CD44

CD44

Inconsistently observed equine MSCs surface marker. Positive human MSCs surface marker according to ISCT

[5, 7, 19, 21]

CD51

ITGAV

Identified on the surface of MSCs derived from equine peripheral blood and AT. Human endothelial cell marker. Upregulated in mouse BM-MSCs during osteoblastic differentiation

[20]

CD71

TFRC

Identified on MSCs derived from equine umbilical cord intervascular matrix

[19]

CD73

NT5E

Inconsistently observed equine MSCs surface marker. Positive human MSCs surface marker according to ISCT

[22]

CD90

THY1

Inconsistently observed equine MSCs surface marker. Positive human MSCs surface marker according to ISCT

[5, 7, 19, 21]

CD105

ENG

Inconsistently observed equine MSCs surface marker. Positive human MSCs surface marker according to ISCT

[7, 19, 21]

CD166

ALCAM

Identified on MSCs derived from equine umbilical cord intervascular matrix

[19]

Identified cluster of differentiation proteins previously reported as present on the surface of human MSCs

CD49a

ITGA1

BM mononuclear stem cell marker for multipotency

[25, 26]

CD49c

ITGA3

Potential predictive stem cell marker for BM-MSCs and AT-MSCs

[27, 28]

CD49d

ITGA4

AT-MSCs surface protein sensitive for cryopreservation

[30]

CD49e

ITGA5

Part of the expression profile of AT-MSCs

[28, 29]

CD56

NCAM1

Negative marker for AT-MSCs

[31]

CD109

CD109

Identified on MSCs derived from equine umbilical cord intervascular matrix

[32, 33]

CD142

F3

Stem cell surface protein, but not specific to MSCs

[34]

Identified cluster of differentiation proteins that have not previously been described in the literature in relation to AT-MSCs or BM-MSCs neither in human nor horse

CD61

ITGB3

Have not previously been described in the literature in relation to AT-MSCs or BM-MSCs neither in human or horse

 

CD91

LRP1

Have not previously been described in the literature in relation to AT-MSCs or BM-MSCs neither in human or horse

 

CD228

MFI2

Have not previously been described in the literature in relation to AT-MSCs or BM-MSCs neither in human or horse

 

CD315

PTGFRN

Have not previously described in the literature studied in relation to AT-MSCs or BM-MSCs neither in human or horse

 
  1. AT-MSCs adipose tissue-derived mesenchymal stromal cells, BM-MSCs bone marrow-derived mesenchymal stromal cells, ISCT International Society for Cellular Therapy