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Table 3 Cluster of differentiation proteins (CD) identified in equine AT-MSCs and/or equine BM-MSCs and their characteristics in relation to AT-MSCs and BM-MSCs described in the literature

From: Mapping of equine mesenchymal stromal cell surface proteomes for identification of specific markers using proteomics and gene expression analysis: an in vitro cross-sectional study

Protein Gene name Characteristics References
Identified cluster of differentiation proteins previously reported as present on the surface of equine MSCs
CD29 ITGB1 Consistently observed equine MSCs surface protein. Positive human MSCs surface marker according to ISCT [5, 7, 19, 21]
CD44 CD44 Inconsistently observed equine MSCs surface marker. Positive human MSCs surface marker according to ISCT [5, 7, 19, 21]
CD51 ITGAV Identified on the surface of MSCs derived from equine peripheral blood and AT. Human endothelial cell marker. Upregulated in mouse BM-MSCs during osteoblastic differentiation [20]
CD71 TFRC Identified on MSCs derived from equine umbilical cord intervascular matrix [19]
CD73 NT5E Inconsistently observed equine MSCs surface marker. Positive human MSCs surface marker according to ISCT [22]
CD90 THY1 Inconsistently observed equine MSCs surface marker. Positive human MSCs surface marker according to ISCT [5, 7, 19, 21]
CD105 ENG Inconsistently observed equine MSCs surface marker. Positive human MSCs surface marker according to ISCT [7, 19, 21]
CD166 ALCAM Identified on MSCs derived from equine umbilical cord intervascular matrix [19]
Identified cluster of differentiation proteins previously reported as present on the surface of human MSCs
CD49a ITGA1 BM mononuclear stem cell marker for multipotency [25, 26]
CD49c ITGA3 Potential predictive stem cell marker for BM-MSCs and AT-MSCs [27, 28]
CD49d ITGA4 AT-MSCs surface protein sensitive for cryopreservation [30]
CD49e ITGA5 Part of the expression profile of AT-MSCs [28, 29]
CD56 NCAM1 Negative marker for AT-MSCs [31]
CD109 CD109 Identified on MSCs derived from equine umbilical cord intervascular matrix [32, 33]
CD142 F3 Stem cell surface protein, but not specific to MSCs [34]
Identified cluster of differentiation proteins that have not previously been described in the literature in relation to AT-MSCs or BM-MSCs neither in human nor horse
CD61 ITGB3 Have not previously been described in the literature in relation to AT-MSCs or BM-MSCs neither in human or horse  
CD91 LRP1 Have not previously been described in the literature in relation to AT-MSCs or BM-MSCs neither in human or horse  
CD228 MFI2 Have not previously been described in the literature in relation to AT-MSCs or BM-MSCs neither in human or horse  
CD315 PTGFRN Have not previously described in the literature studied in relation to AT-MSCs or BM-MSCs neither in human or horse  
  1. AT-MSCs adipose tissue-derived mesenchymal stromal cells, BM-MSCs bone marrow-derived mesenchymal stromal cells, ISCT International Society for Cellular Therapy
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Stem Cell Research & Therapy

ISSN: 1757-6512