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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Impact of one versus two doses of mesenchymal stromal cells on lung and cardiovascular repair in experimental emphysema

Fig. 4

Two doses of MSCs, but not a one-dose regimen, led to immunosuppression in the thymus. a Thymus weight, b total cell count, c CD4+ T cells, d CD8+ T cells, and e CD4+CD25+Foxp3+ cell counts in thymus. CTRL control mice, E emphysema mice, SAL saline-treated mice, MSC MSC-treated group, MSCs mesenchymal stromal cells. For statistical comparison, the following tests were used: one-way ANOVA followed by Tukey’s test in panels a, b and Kruskal–Wallis test followed by Dunn’s test in panels ce. Data are presented as means ± SD (a, b) or median ± interquartile range (ce). N = 10 animals/group. *Significantly different from CTRL (p < 0.05). #Significantly different from E-SAL (p < 0.05). Significantly different from E-MSC-1 dose (p < 0.05)

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