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Table 1 Lung morphometry

From: Impact of one versus two doses of mesenchymal stromal cells on lung and cardiovascular repair in experimental emphysema

 

Normal (%)

Collapse (%)

Hyperinflation (%)

Lm (μm)

Neutrophils (%)

Mononuclear cells (%)

CTRL

91.7 ± 2.1

8.3 ± 2.1

0.0 ± 0.0

22.3 ± 5.1

1.6 ± 0.7

33.8 ± 2.3

E

SAL

18.4 ± 4.9*

27.2 ± 8.6*

54.4 ± 9.9*

50.3 ± 6.7*

7.3 ± 0.8*

42.4 ± 3.6*

MSC

1 dose

41.5 ± 4.8*,#

15.9 ± 4.8*,#

42.6 ± 4.1*,#

33.4 ± 2.8*,#

2.9 ± 0.9*,#

31.6 ± 4.0#

2 doses

51.4 ± 11.3*,#,ǂ

17.9 ± 4.4*,#

30.7 ± 6.3*,#,ǂ

29.8 ± 4.2*,#,ǂ

1.7 ± 0.5#,ǂ

36.1 ± 3.3#

  1. Volume fraction of normal, collapsed, and hyperinflated pulmonary areas, mean linear intercept (Lm), and neutrophil and mononuclear cell counts in lung tissue. One-way ANOVA followed by Tukey’s test was used for statistical comparison. Data are presented as means ± SD. N = 10 animals/group
  2. CTRL control mice, E emphysema mice, SAL saline-treated mice, MSC MSC-treated mice
  3. *Significantly different from CTRL (p < 0.05)
  4. #Significantly different from E-SAL (p < 0.05)
  5. ǂSignificantly different from E-MSC-1 dose (p < 0.05)