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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells

Fig. 3

TDP43 expression and aggregation in iPSC-derived neurons. a Immunofluorescent image of TDP43 expression in WT, TDP43, and sporadic MN. Translocation of TDP43 was found in G298S TDP43 MN. Scale bar = 50 μm. b TDP43 immuno-EM in neurites, cytoplasm and nuclei of MN cultures. TDP43 MN had a lot of small gold particles in the neurites and cytoplasm, while sporadic MNs had gold particle clusters. Arrows = clusters of gold particles. No contrast staining for ALS MNs for better view of fine gold particles. Scale bar = 2 μm. c Representative Western blots and relative TDP43 expression levels (to GAPDH) in MNs

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