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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Metformin induces apoptosis in mesenchymal stromal cells and dampens their therapeutic efficacy in infarcted myocardium

Fig. 4

Counteraction of AMPK partially restored MSC cardioprotective effects in diabetic mice with MI. a Representative images of TTC-stained heart sections obtained from sham, MI + PBS, MI + metformin, MI + MSCs, MI + metformin + MSCs, and MI + metformin + MSCs + compound C groups at 4 weeks after MI. b LV infarct sizes expressed as the ratio of the area of the infarct band to the total area of LV (n = 28). c Representative M-mode images of hearts with sham surgery or MI at 4 weeks after PBS, metformin, MSCs, metformin + MSCs, and metformin + MSCs + compound C treatment. Scale bar: X axis: 0.1 s; Y axis: 0.2 cm. d Heart rates were controlled to be similar in different groups. eg LV fraction shortening (e), LV ejection fraction (f), and diastolic left ventricle internal diameter (LVIDd, g) at 4 weeks after treatment (n = 28). *p < 0.05 vs. sham; #p < 0.05 vs. MI + metformin; &p < 0.05 vs. MI + MSCs; ɸp < 0.05 vs. MI + metformin + MSCs, by one-way ANOVA

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