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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells

Fig. 2

Representative image of the anti-angiogenic potential of autophagy. Anti-angiogenic effect autophagy is initiated via the modulation of Wnt/β-catenin axis. The application of autophagy inducer, magnolol (Ery5), has an inhibitory effect on migration and tube formation properties in both human umbilical vein endothelial cells and apoptotic resistant cancer cells while chemical blocking of autophagy by 3-MA or gene silencing of Atg7 and LC3 reversed anti-angiogenic effect of autophagy VEGFR-2 levels and angiogenesis are reduced following endothelial dysfunction and exposure to advanced glycation end products (AGEs) accumulation under diabetic condition. Autophagy plays a key role in VEGFR-2 degradation and impaired angiogenesis. Gastrin-releasing peptide (GRP) and its receptor GRPR through PI3K-AKT pathway have a pivotal role in cancer-related angiogenesis. By antagonizing GRPR, pro-autophagic proteins are overexpressed and angiogenesis blocked by autophagy-mediated GRP degradation mechanism

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