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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration

Fig. 7

GFP staining for tracing donor cells in the regenerated bone. a We found GFP-positive cells in all donor cell groups in young and old animal hosts. The boxed area is an enlarged image from each original image. b Quantification of GFP-positive cells in young and old hosts. We found that there were fewer GFP-positive cells in old hosts when compared to young hosts when old donor 1, young donor 2, and old donor 2 cells were used (*P < 0.05). There were no significant differences between young and old hosts when using the other donor cells. c Comparison of GFP-positive cells of young and old donor cells. We found differences in the number of GFP-positive cells between young and old donor cells in both young and old hosts. When we transplanted cells in young hosts, we found more GFP-positive cells when using old donor 1 cells compared to using young donor 1 cells. We found the same results when we compared old donor 3 cells and young donor 3 cells. However, the opposite was found when comparing old donor 2 to young donor 2 cells. In old hosts, we found fewer GFP-positive cells when using old donor 2 cells compared to young donor 2 cells. No differences were found when we compared young donor 1 and old donor 1 or young donor 3 and old donor 3 in old hosts. *P < 0.05, **P < 0.01

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