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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration

Fig. 8

TRAP staining to reveal bone remodeling. a TRAP staining for each donor group in young and old host mice. The boxed area is enlarged from each specified respective small box in the original images (× 200). b Quantification of TRAP-positive cells in the regenerated bone area. We found significantly more TRAP-positive cells in old hosts when we used old donor 1 and young donor 2 LBMP2/GFP-transduced hMDSCs compared to TRAP-positive cells found in young hosts. No statistically significant differences were found between young and old hosts when using other donor cells. c Significantly lower levels of serum IGF1 were found in old hosts compared to young hosts. d No significant differences were found for serum sclerostin levels in young and old hosts. e A trend of increased serum RANKL levels was found in old hosts compared to young hosts, but differences were not found to be significant. *P < 0.05, **P < 0.01

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