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Table 2 Characteristics of the selected 11 compounds of stem cell signaling library

From: Stem cell library screen identified ruxolitinib as regulator of osteoblastic differentiation of human skeletal stem cells

Name of compound Target Pathway
LY411575 Gamma-secretase Proteases
Sotrastaurin PKC TGF-beta/Smad
SB525334 TGF-beta/Smad TGF-beta/Smad
Ruxolitinib (INCB018424) JAK1/JAK2 JAK/STAT
LGK-974 Wnt/beta-catenin Stem cells and Wnt
ICG-001 Wnt/beta-catenin Stem cells and Wnt
TWS119 GSK-3 PI3K/Akt/mTOR
Fasudil (HA-1077) HCl ROCK Cell cycle
Baricitinib (LY3009104, INCB028050) JAK Epigenetics
BMS-833923 Hedgehog/smoothened GPCR and G protein