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Table 2 Characteristics of the selected 11 compounds of stem cell signaling library

From: Stem cell library screen identified ruxolitinib as regulator of osteoblastic differentiation of human skeletal stem cells

Name of compound

Target

Pathway

LY411575

Gamma-secretase

Proteases

Sotrastaurin

PKC

TGF-beta/Smad

SB525334

TGF-beta/Smad

TGF-beta/Smad

Ruxolitinib (INCB018424)

JAK1/JAK2

JAK/STAT

LGK-974

Wnt/beta-catenin

Stem cells and Wnt

ICG-001

Wnt/beta-catenin

Stem cells and Wnt

BIO

GSK-3

PI3K/Akt/mTOR

TWS119

GSK-3

PI3K/Akt/mTOR

Fasudil (HA-1077) HCl

ROCK

Cell cycle

Baricitinib (LY3009104, INCB028050)

JAK

Epigenetics

BMS-833923

Hedgehog/smoothened

GPCR and G protein