Fig. 5

Relationship between adoption of experimental model in vivo (animal model) and in vitro (culture format) and outcome of naïve MSC-based cancer cytotherapy experiments. a In vivo. Bar of pie chart categories denote relative contribution of MSCs to the most frequently observed outcome for each animal model. Naïve MSC plus naïve MSC used as controls for GM-MSC-focused work were used to derive total sample size. For experiments on athymic- nude mice, N = 30. For experiments on SCID mice, N = 17. b In vitro. Co-C = direct or indirect co-culture of naïve MSC with cancer cells. C.Med = use of naïve MSC-conditioned media on cancer cells. Sample sizes: N = 23/29/29, for AT-/BM-/UC-MSC, respectively