Fig. 1

SGJ co-located with lysosomes. a The chemical structure of SGJ, 3-butyl-1-chloro imidazo [1, 5-a] pyridine-7-carboxylic acid. b Lysosomal co-localization experiment. BMSCs were treated with 0.1% DMSO (as control) or 20 μM SGJ for 1 h, and then treated cells with 0.5 μM LysoTracker® Red DND-99 for 30 min. Monitored the red and blue fluorescence by a confocal laser scanning microscope, and calculated the co-localization coefficient is 0.94