Skip to main content
Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Overexpression of apelin in Wharton’ jelly mesenchymal stem cell reverses insulin resistance and promotes pancreatic β cell proliferation in type 2 diabetic rats

Fig. 6

WJMSC-apelin infusion improved insulin sensitivity in T2D rats. a Individual oral glucose tolerance was assessed by OGTTs 6 weeks after MSC-apelin infusion. T2D rats with WJMSC-apelin infusion (n = 5) have lower fasting blood glucose and an improved glucose tolerance compared with saline infusion group. b Area under curve (AUC) for the glucose tolerance test is calculated using standard methods. c Insulin tolerance was evaluated by IPITTs in T2D rats with WJMSC-apelin or saline infusion (each group, n = 5). There was a severe insulin resistance in T2D-saline rats, but no sign of insulin resistance in WJMSC-apelin infusion T2D rats. d AUC for insulin tolerance is calculated using standard methods. T2D+saline: type 2 diabetic rat with saline infusion; T2D+WJMSC-apelin: type 2 diabetic rat with Wharton’s jelly mesenchymal stem cell-apelin infusion

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512