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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Induced pluripotent stem cell-derived endothelial progenitor cells attenuate ischemic acute kidney injury and cardiac dysfunction

Fig. 7

Systemic human iPS cell-derived iEPC therapy attenuated apoptosis of cardiomyocytes in acute kidney injury (AKI) mice. a Representative immunofluorescence images depicting TUNEL+ cells in the left ventricles on day 2 after sham or AKI. Arrows indicate TUNEL+ (green) nuclei (blue) and cardiomyocytes staining. Scale bar = 100 μm. b Bar chart illustrating quantitative analyses of TUNEL+ apoptotic cells per high-power field (× 200 magnification) in the left ventricle on day 2 after sham or AKI. N = 8 per group. c, d Representative images of Western blot analyses of caspase 3 and Bcl-2 in the left ventricles on day 2 after sham or AKI. GAPDH was used as the control of protein loading. Bar charts illustrating quantitative analyses. N = 3 per group. Data are presented as mean ± SEM. *P < 0.05 AKI-V vs. Sham, #P < 0.05 AKI-iEPC vs. AKI-V group

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Stem Cell Research & Therapy

ISSN: 1757-6512