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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis

Fig. 1

Generation of iPSCs from healthy control subjects and RA patients with MTX-induced hepatotoxicity. a Scheme of generation of iPSCs from healthy controls and RA patients with MTX-induced hepatotoxicity. b Induction of iPSCs derived from RA patients with hepatotoxicity. c Real-time PCR data for pluripotency gene expression in iPSCs. d RT-PCR data for pluripotency gene expression in iPSCs. e Flow cytometry data of iPSCs showing a population of OCT3/4-positive cells. f Immunocytochemistry images showing that pluripotent markers (SSEA4, OCT3/4, TRA-1-60, Sox 2, TRA-1-81, and Klf4) were expressed in iPSCs from healthy control (HC)- and RA patient (RA)-iPSCs. Scale bars, 200 μm

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