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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide

Fig. 6

The role of iNOS in IFNγ/TNFα-induced apoptosis of MSCs. MSCs undergo apoptosis due to the synergistic action of IFNγ and TNFα under an inflammatory microenvironment. The pro-inflammatory cytokines IFNγ and TNFα induce apoptosis of mouse BM-MSCs in an NO-dependent manner. NO impairs autophagy in BM-MSCs and contributes to ER stress. NO also upregulates Fas and enhances Fas-mediated apoptosis

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