Fig. 6From: IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxideThe role of iNOS in IFNγ/TNFα-induced apoptosis of MSCs. MSCs undergo apoptosis due to the synergistic action of IFNγ and TNFα under an inflammatory microenvironment. The pro-inflammatory cytokines IFNγ and TNFα induce apoptosis of mouse BM-MSCs in an NO-dependent manner. NO impairs autophagy in BM-MSCs and contributes to ER stress. NO also upregulates Fas and enhances Fas-mediated apoptosisBack to article page