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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification

Fig. 4

Characterization of the candidate niche supportive cells. a Typical image of double staining of CldU+/SMI312. White arrows point to the close association but not co-localization of CldU+ stem cells with SMI312+ neurites. b Typical image of triple staining of CldU+/SMI312/Typ. White arrows point to close association but not co-localization of CldU+ stem cells with Typ + mast cells. c Typical image of double staining of (end/lam). Note the almost 100% association but not co-localization of end with lam (end is always on the luminal side). d Typical image of double staining of (CldU/lam). White arrows point to close association but not co-localization of CldU+ stem cells with lam + vasculature. e, f Macrophages were associated with HO. e Abundant IBA1+ macrophages were present in the lesion from the earliest stage. f IBA1+ macrophages were closely associated with the proposed MSC niche. In all panels, the dashed white lines demarcate the proposed MSC niche. Bar = 50 μm

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