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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Fig. 1

Characterization of bone marrow-derived MSCs and Fstl1 expression under hypoxic condition. a Morphology of murine bone marrow-derived MSCs in culture. These cells are adherent to bottom of plastic dishes. The majority of MSCs exhibit spindle or triangular shapes. Scale bar = 50 μm. bg Most MSCs express mesenchymal stem cell marker CD29 (b), CD44 (c), CD90 (d), and Sca-1 (e), whereas most MSCs do not express hematopoietic marker CD45 (f) and progenitor marker CD117 (g). Unstained and isotype controls are indicated by red and green spectra, respectively. h qRT-PCR analysis of Fstl1 mRNA levels in hypoxic MSCs (n = 5). ***P < 0.001, HP24 and HP48 versus HP0. HP, hypoxia

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