Table 2 MT enhances MSC activity to rescue the function of multiple organs by alleviating inflammation, apoptosis, and oxidative stress
Animal | Disease | Dose | MSC resource | Effect | Mechanism | Ref |
|---|---|---|---|---|---|---|
C57BL/6a mice | Myocardial infarction | 5 μM | Adipose | Heart function↑ | SIRT1↑ | [14] |
Male ICR mice | Skin wound | 1 μM | Umbilical cord blood | Wound closure↑; granulation↑; re-epithelialization↑ | MT2-mediated pathway↑ | [8] |
Adult male Sprague Dawley rats | Focal cerebral ischemia | 0.05 to 1 mM | Bone marrow | Brain infarction↓; neurobehavioral outcomes↑ | ERK1/2 ↑ | [9] |
Adult male Sprague Dawley rats | Liver fibrosis | 5 μM | Bone marrow | Glycogen storage↑; collagen and lipid accumulation↓ | TGF-β1 and Bax/Bcl2↓ | [10] |
Male albino rats | Diabetes | 10 mg/kg for 8 weeks | Bone marrow | Structural and functional efficiency of β-cells in the pancreas↑ | Antioxidant↑ | [11] |
Adult male Sprague Dawley rats | Acute kidney injury | After the procedure, 20 mg/kg at 30 min, 50 mg/kg at 6 h and 18 h | Adipose | Sepsis induced acute kidney injury↓ | Inflammation↓, inappropriate immune response↓, ROS generation↓, oxidative stress↓ | [12] |
Male BALB/c nude mice | Limb ischemia | After procedure, 20 mg/kg/day for 28 days | Adipose | MSC functionality↑; neovascularization↑ | PrPC expression↑ | [55] |
Adult male Sprague Dawley rats | Small bowel ischemia reperfusion | After the procedure: 20 mg/kg, 50 mg/kg at 6 h and 18 h | Adipose | Ischemia reperfusion injury↓ | Inflammation↓, oxidative stress↓, apoptosis↓, mitochondrial damage↓, DNA damage↓, antioxidant enzymes↑ | [66] |
Adult male Sprague Dawley rats | Acute interstitial cystitis | After the procedure, 20 mg/kg at 30 min, 50 mg/kg at 6 h and 18 h | Adipose | Cyclophosphamide-induced acute interstitial cystitis↓ | Antioxidants↑ | [67] |
Adult male Wistar strain Albino rats | Diabetic nephropathy | 5 μM | Bone marrow | Kidney functions↑ | Pathogenic factors↓, autophagy↑ | [68] |