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Table 2 MT enhances MSC activity to rescue the function of multiple organs by alleviating inflammation, apoptosis, and oxidative stress

From: Melatonin plays critical role in mesenchymal stem cell-based regenerative medicine in vitro and in vivo

Animal Disease Dose MSC resource Effect Mechanism Ref
C57BL/6a mice Myocardial infarction 5 μM Adipose Heart function↑ SIRT1↑ [14]
Male ICR mice Skin wound 1 μM Umbilical cord blood Wound closure↑; granulation↑; re-epithelialization↑ MT2-mediated pathway↑ [8]
Adult male Sprague Dawley rats Focal cerebral ischemia 0.05 to 1 mM Bone marrow Brain infarction↓; neurobehavioral outcomes↑ ERK1/2 ↑ [9]
Adult male Sprague Dawley rats Liver fibrosis 5 μM Bone marrow Glycogen storage↑; collagen and lipid accumulation↓ TGF-β1 and Bax/Bcl2↓ [10]
Male albino rats Diabetes 10 mg/kg for 8 weeks Bone marrow Structural and functional efficiency of β-cells in the pancreas↑ Antioxidant↑ [11]
Adult male Sprague Dawley rats Acute kidney injury After the procedure, 20 mg/kg at 30 min, 50 mg/kg at 6 h and 18 h Adipose Sepsis induced acute kidney injury↓ Inflammation↓, inappropriate immune response↓, ROS generation↓, oxidative stress↓ [12]
Male BALB/c nude mice Limb ischemia After procedure, 20 mg/kg/day for 28 days Adipose MSC functionality↑; neovascularization↑ PrPC expression↑ [55]
Adult male Sprague Dawley rats Small bowel ischemia reperfusion After the procedure: 20 mg/kg, 50 mg/kg at 6 h and 18 h Adipose Ischemia reperfusion injury↓ Inflammation↓, oxidative stress↓, apoptosis↓, mitochondrial damage↓, DNA damage↓, antioxidant enzymes↑ [66]
Adult male Sprague Dawley rats Acute interstitial cystitis After the procedure, 20 mg/kg at 30 min, 50 mg/kg at 6 h and 18 h Adipose Cyclophosphamide-induced acute interstitial cystitis↓ Antioxidants↑ [67]
Adult male Wistar strain Albino rats Diabetic nephropathy 5 μM Bone marrow Kidney functions↑ Pathogenic factors↓, autophagy↑ [68]