Fig. 10
EPC-Exos enhanced the expression of angiogenesis-related genes. a Expression of angiogenesis-related genes in HUVECs treated with EPC-Exos (1 × 1011 particles/ml) or PBS using qRT-PCR. b Detection of HIF-1α levels in HUVECs treated with serial concentrations of EPC-Exos (0, 4 × 109, 2 × 1010, and 1 × 1011 particles/ml) by western blot. c Concentrations of VEGF, TGF-β1, and angiogenin in the supernatants of HUVECs by ELISA. *P < 0.05, **P < 0.01, ***P < 0.001 vs PBS. HUVECs human umbilical vein endothelial cells, Exo exosomes secreted by endothelial progenitor cells, PBS phosphate-buffered saline