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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Exosomes secreted by endothelial progenitor cells accelerate bone regeneration during distraction osteogenesis by stimulating angiogenesis

Fig. 8

EPC-Exos enhanced the proliferation, migration, and angiogenic ability of HUVECs via miR-126. a Wound healing assay was used to evaluate the effect of EPC-Exos on the motility of HUVECs. b The tube formation assay was performed to assess the angiogenic capability of HUVECs treated with EPC-Exos or PBS. c Quantitative analysis of migration area indicated that EPC-Exos significantly enhanced the motility of HUVECs via miR-126. d, e Qualification of the branch points and total tube length indicated the increased angiogenic capability of HUVECs treated with EPC-Exos via miR-126. f The results of CCK-8 assay showed that EPC-Exos promoted proliferation of HUVECs, and a higher dose of exosomes exerted a better effect. *P < 0.05, #P < 0.001. HUVECs human umbilical vein endothelial cells, Exo exosomes secreted by endothelial progenitor cells, PBS phosphate-buffered saline

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