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Table 2 Baseline characteristics of treated limbs and transplants

From: Predictors of responders to mononuclear stem cell-based therapeutic angiogenesis for no-option critical limb ischemia

 

Total, n = 103

Responders, n = 58

Non-responders, n = 45

P value

Rutherford class, n (%)

 IV

12 (11.6%)

5 (8.6%)

7 (15.6%)

0.277

 V

91 (88.4%)

53 (91.4%)

38 (84.4%)

0.277

Gangrene, n (%)

    

 Yes

46 (44.7%)

25 (43.1%)

21 (46.7%)

0.718

 No

57 (55.3%)

33 (56.9%)

24 (53.3%)

0.718

ABI* (median [IQR])

0.485 (0.370–0.640)

0.515 (0.410–0.695)

0.430 (0.280–0.540)

0.011

TcPO2 (mmHg) (median [IQR])

17 (6–28)

24 (14–30)

9 (4–19)

< 0.001

Highest level of arterial occlusion

Above the knee or elbow, n (%)

62 (60.2%)

28 (46.6%)

34 (77.8%)

0.001

Common or external iliac artery, n (%)

4 (3.9%)

1 (1.7%)

3 (6.7%)

0.198

Common femoral artery or axillary artery, n (%)

5 (4.8%)

4 (6.9%)

1 (2.2%)

0.383

Superficial femoral artery or brachial artery, n (%)

36 (35.0%)

15 (25.9%)

21 (46.7%)

0.037

Popliteal artery, n (%)

17 (16.5%)

7 (12.1%)

10 (22.2%)

0.169

Below the knee or elbow, n (%)

41 (39.8%)

31 (53.4%)

10 (22.2%)

0.001

Artery in the calf or forearm, n (%)

28 (27.2%)

23 (39.7%)

5 (11.1%)

0.001

Artery below the ankle or wrist, n (%)

13 (12.6%)

8(13.7%)

5 (11.1%)

0.684

Type of transplantation

Purified for CD34+ cells, n (%)

52 (50.5%)

30 (51.7%)

22 (48.9%)

0.775

Not purified, n (%)

51 (49.5%)

28 (48.3%)

23 (51.1%)

0.775

Total transplanted CD34+ cells (million/L) (median [IQR])

43.0 (26.0–84.0)

51.5 (26.0–103.0)

40.0 (26.0–68.0)

0.114

Cell viability (median [IQR])

98.4% (97.7%–98.6%)

98.3% (97.5%–98.6%)

98.4% (98.2%–98.6%)

0.212

  1. *ABIs of 99 patients with lower limbs treated were included in this analysis, while the other 4 patients with upper limbs treated were excluded
  2. IQR, interquartile range; ABI, ankle-brachial index; TcPO2: transcutaneous pressure of oxygen; CD, cluster of differentiation