Fig. 1

Schematic figure of myogenesis as well as the study design. The leftmost part of the figure shows the adult myogenic process, from activation of skeletal muscle stem cells to a mature myofibre, as it occurs naturally in vivo. The rightmost part shows our study design covering the different analyses of genome-wide DNA methylation and gene expression in primary human myoblasts and in vitro differentiated myotubes from women and men. BMI, body mass index; Wilcoxon, Wilcoxon signed-rank test