Fig. 2
From: Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes
Differential DNA methylation and gene expression in human myoblasts from women and men. a Manhattan plot of all analysed CpG sites for DNA methylation in myoblasts from women versus men. The blue line indicates the threshold for significance (q < 0.05). Green dots indicated with arrows are selected CpG sites for some genes of interest. Manhattan plot with black points are CpG sites only on the X-chromosome. N = 13 for both women and men. b, c A selection of relevant significant KEGG pathways (q < 0.05) from GSEA of expression data in myoblasts from women versus men (N = 11–13). Total, total number of genes in the pathway in the analysed dataset; Observed, observed number of genes in the dataset contributing to the enrichment; Val, valine; Leu, leucine; Ile, isoleucine; Gnrh, gonadotropin-releasing hormone; TGF-beta, transforming growth factor-beta. d Gene expression of selected genes in metabolic pathways and e DNA methylation of significant CpG sites annotated to these genes in myoblasts from women and men. *, q < 0.05, N = 11–13. Data are presented as mean ± SD