Fig. 4
From: Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes
Differential DNA methylation and gene expression in human myotubes from women and men. a Manhattan plot of all analysed CpG sites for DNA methylation between women and men in myotubes. The blue line indicates the threshold for significance (q < 0.05). Green dots indicated with arrows are selected CpG sites for some genes of interest. Manhattan plot with black points are CpG sites only on the X-chromosome. N = 13 for both women and men. b A selection of relevant significant KEGG-pathways (q < 0.05) from GSEA of expression data for women versus men in myotubes (N = 11–13). *, pathways enriched in both myoblasts and myotubes; Total, total number of genes in the pathway in the analysed dataset; Observed, observed number of genes in the dataset contributing to the enrichment