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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases

Fig. 3

OCT4 inhibited senescence in hHFMSCs. a qPCR results for the expression of senescence-associated genes. CDKN1A, p21; CDKN2A, p16. b Effects of OCT4 on hHFMSCs under transmission electron microscopy. White arrow, dilation of the rough endoplasmic reticulum; black arrow, turgidity and vacuolization of the mitochondrion. c SA-β-gal staining in hHFMSCsEGFP and hHFMSCsOCT4 (bar, 200 μm). Stained cells are indicated by arrows (**p < 0.01)

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Stem Cell Research & Therapy

ISSN: 1757-6512